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21. Hyuck Jin Lee, Young Geun Lee, Juhye Kang, Seung Hyun Yang, Ju Hwan Kim, Amar B. T. Ghisaidoobe, Hyo Jin Kang,* Sang-Rae lee,*, Mi Hee Lim,* and Sang J. Chung* Chem. Sci. 2019, 10, 1000-1007. (Co-first authorship)

“Monitoring MetalAmbyloid-b Complexation by a FRET-based Probe: Design, Detection, and Inhibitor Screening”

*Note: This paper was selected as a “2018 Chemical Science HOT Article” and highlighted as the Back Cover.

 

20. Misun Lee, Mingeun Kim, Anjong Florence Tikum, Hyuck Jin Lee, Vijayan Thamilarasan, Mi Hee Lim,* and Jinheung Kim* Dyes Pigm. 2019, 162, 97-103.

“A Near-Infrared Fluorescent Probe for Amyloid-b Aggregates”

 

19. Masha G. Savelieff, Geewoo Nam, Juhye Kang, HyuckJinLee, Misun Lee, and Mi Hee Lim* Chem. Rev. 2019, 119, 1221-1322.

“Development of Multifunctional Molecules as Potential Therapeutic Candidates for Neurodegenerative Diseases in the Last Decade”

*Note: This paper was for the Special Issue of “Metals in Medicine”.

 

18. Hyuck Jin Lee,Masha G. Savelieff,Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Shin Jung C. Lee, Elizabeth M. Nolan,* and Mi Hee Lim* Metallomics 2018, 10, 1116-1127. (Co-first authorship)

“Calprotectin Influences the Aggregation of Metal-free and Metal-bound Amyloid-b by Direct Interaction”

 

17. Sonam Kim,HyuckJinLee,Eunju Nam,Donghyun Jeong, Jaeheung Cho, Mi Hee Lim,* and Youngmin You* ACS Omega 2018, 3, 5141-5154. (Co-first authorship)

“Tailoring Hydrophobic Interactions between Probes and Amyloid-b Peptides for Fluorescent Monitoring Amyloid-b Aggregation”

 

16 Jiyeon Han, HyuckJinLee, Kyu Yeon Kim, Shin Jung C. Lee, Jong-Min Suh, Jaeheung Cho, Junghyun Chae,* and Mi Hee Lim* ACS Chem. Neurosci. 2018, 9, 800-808.

“Tuning Structures and Properties for Developing Novel Chemical Tools Towards Distinct Pathogenic Elements in Alzheimer's Disease”

 

15. Tae Su Choi,HyuckJinLee,Jong Yoon Han, Mi Hee Lim,* and Hugh I. Kim* J. Am. Chem. Soc. 2017, 139, 15437-15445. (Co-first authorship)

“Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-b in the Extracellular Region”

*Note: This paper was highlighted as the Front Cover.

 

14. Yonghwan Ji,HyuckJinLee,Minjeon Kim, Geewoo Nam, Shin Jung C. Lee, Jaeheung Cho, Cheol-Min Park,* and Mi Hee Lim* Inorg. Chem. 2017, 56, 6695-6705. (Co-first authorship)

"Strategic Design of 2,2’-Bipyridine Derivatives to Modulate MetalAmyloid-b Aggregation"

 

 

13. Hyuck Jin Lee, Kyle J. Korshavn, Younwoo Nam, Juhye Kang, Thomas J. Paul, Richard A. Kerr, Il Seung Youn, Mehmet Ozbil, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim* Chem. Eur. J. 2017, 23, 2706-2715.

"Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease"

 

12. Juhye Kang, Shin Jung C. Lee, Jung Seung Nam, HyuckJinLee, Myeong-Gyun Kang, Kyle J. Korshavn, Hyun-Tak Kim, Jaeheung Cho, Ayyalusamy Ramamoorthy, Hyun-Woo Rhee,* Tae-Hyuk Kwon,* and Mi Hee Lim* Chem. Eur. J. 2017, 23, 1645-1653.

“An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation”

*Note: This paper was selected as an Editor’s Choice: Spotlights from both ChemPubSoc Europe and Asian Chemical Editorial Society (ACES)

*Note: This paper was selected as a “HOT Paper”

 

11. Shin Jung C. Lee, Eunju Nam, HyuckJinLee, Masha G. Savelieff, and Mi Hee Lim* Chem. Soc. Rev. 2017, 46, 310-323.

“Towards an Understanding of Amyloid-β Oligomers; Characterisaton, Toxicity Mechanism, and Inhibitors”

 

10. Shin Jung Lee, Tae Su Choi, Jong Wha Lee, HyuckJinLee, Dong-Gi Mun, Milim Jang, Satoko Akashi, Sang-Won Lee, Mi Hee Lim,* and Hugh I. Kim* Chem. Sci. 2016, 7, 5398-5406.

“Structure and Assembly Mechanisms of Toxic Human Islet Amyloid Polypeptide Oligomers Associated with Copper”

 

9. Hyuck Jin Lee, Richard A. Kerr, Kyle J. Korshavn, Jeeyeon Lee, Juhye Kang, Ayyalusamy Ramamoorthy,* Brandon, T. Ruotolo,* and Mi Hee Lim* Inorg. Chem. Front. 2016, 3, 381-392.

“Effects of Hydroxyl Group Variations on a Flavonoid Backbone toward Modulation of Metal-free and Metal-induced Amyloid-b Aggregation”

*Note: This paper was selected as the themed issue of HOT articles in Inorganic Chemistry Frontiers for 2016; themed issue of 2015 Emerging Investigators by Inorg. Chem. Front.

 

8. Jeffrey Derrick, Richard A. Kerr, Younwoo Nam, Shin Bi Oh, HyuckJinLee, Kaylin Earnest, Nayoung Suh, Kristy Peck, Mehmet Ozbil, Kyle Korshavn, Ayyalusamy Ramamoorthy, Rajeev Prabhakar, Edward Merino, Jason Shearer,* Joo-Yong Lee,* Brandon Ruotolo,* and Mi Hee Lim* J. Am. Chem. Soc. 2015, 137, 14785-14797.

“A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms”

*Note: This paper was highlighted in multiple news media (The Korea Economic Daily; Dong-A Science; The Kyunghyang Sinhmun; Yonhap News).

 

7. Michael W. Beck, Shin Bi Oh, Richard A. Kerr, HyuckJinLee, So He Kim, Sujeong Kim, Milim Jang, Brandon T. Ruotolo,* Joo-Yong Lee,* and Mi Hee Lim* Chem. Sci. 2015, 6, 1879-1886.

“A Rationally Designed Small Molecule for Identifying an in vivo Link between Metal-Amyloid-b Complexes and the Pathogenesis of Alzheimer’s Disease”

*Note: This paper was selected by F1000Prime.

 

6. Akiko Kochi, HyuckJinLee, Sashiprabha M. Vithanarachchi, Vediappen Padmini, Matthew J. Allen,* and Mi Hee Lim* Curr. Alzheimers Res. 2015, 12, 415-423.

“Inhibitory Activity of Curcumin Derivatives towards Metal-Free and Metal-Induced Amyloid-b Aggregation”

 

5. Alaina S. DeToma,JanarthananKrishnamoorthy,YounwooNam,HyuckJinLee, Jeffery R. Brender, Akiko Kochi, Dongkuk Lee, Valentina Onnis, Cenzo Congiu, Stefano, Manfredini, Silvia Vertuani, Gianfranco Balboni,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim* Chem. Sci. 2014,,4851-4862.

“Interaction and Reactivity of Synthetic Aminoisoflavones with Metal-Free and Metal-Associated Amyloid-b”

 

4. Hyuck Jin Lee, Younwoo Nam, and Mi Hee Lin*chemworld 2014.54,22-27

“Development of Chemical Tools for Studying MetalAmyloid-b in Alzheimer’s Disease”

 

3. Hyuck Jin Lee,Kyle J. Korshavn,Akiko Kochi, Jeffrey S. Derrick, and , 43, 6672-6682. (Co-first authorship)

Cholesterol and Metal Ions in Alzheimer's Disease”

 

2. Masha G. Savelieff, Yuzhong Liu, Russell R. P. Senthamarai, Kyle J. Korshavn, HyuckJinLee, Ayyalusamy Ramamoorthy,* and Mi Hee Lim* Chem. Commun. 2014, , 5301-5303.

“A Small Molecule that Displays Marked Reactivity toward Copperversus ZincAmyloid-β Implicated in Alzheimer’s Disease”

*Note: This paper was selected as the top 10% of highly cited articles from the RSC General Chemistry portfolio of Journals.

 

1. Sanghyun Lee, Xueyun Zheng, Janarthanan Krishnamoorthy, Masha G. Savelieff, Hyun Min Park, Jeffrey R. Brender, Jin Hoon Kim, Jeffrey S. Derrick, Akiko Kochi, HyuckJinLee, Cheal Kim, Ayyalusamy Ramamoorthy,* Michael T. Bowers,* and Mi Hee Lim* J. Am. Chem. Soc. 2014, 136, 299-310.

“Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease”

*Note: This paper was highlighted in multiple news media (UBC broadcast); in March and April of 2016, this paper was highly cited as 1% of the Chemistry field (Web of Science)..

 

 

수상경력 및 학회 활동

 

 

2018. 06.                             Poster Award

                                            The 2018 Korea Chemical Society Inorganic Chemistry Division Summer Symposium, Busan, Korea 

 

2016. 07.                             Poster Award

                                            The 2016 Bioinorganic Chemistry Symposium, Suanbo, Korea 

 

2015. 08.                             Rackham Travel Fellowship

                                            University of Michigan, Ann Arbor, MI, USA 

 

2014. 07.                             Travel Bursary Award

                                            The 7th Asian Biological Inorganic Chemistry Conference, Gold Coast, Australia

 

 2011. 05.                             Cum Laude

                                            Minnesota State University, Mankato, MN, USA

 

 2010                                    Undergraduate Research Grant

Undergraduate Research Center, Minnesota State University, Mankato, MN, USA 

 

2009 2010                        Dean’s list

 Department of Chemistry and Geology, Minnesota State University, Mankato, MN, USA 

 

2009                                    Undergraduate Award in Inorganic Chemistry

                                            Division of Inorganic Chemistry, American Chemical Society 

 

2007 – 2011                       Students Representative

                                           Dual Degree Program, Catholic University of Daegu, Korea

and Minnesota State University, Mankato, MN, USA 

 

2007 – 2011                       Full-Scholarship

Catholic University of Daegu, Korea

and Minnesota State University, Mankato, MN, USA

 

 

 

Reviewer for Peer-Reviewed Journals

: Curr. Alzheimers Res., MedChemComm, RSC Adv.

학회 발표

21. Poster, The 2018 Daejeon, Chungnam, Sejong Region Symposium of Korean Chemical Society, Daejeon, Korea, October 26, 2018

Hyuck Jin Lee, Masha G. Savelieff, Tae Su Choi, Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Elizabeth M. Nolan, Hugh I. Kim, and Mi Hee Lim*

“Molecular-Level Studies of Amyloid-b with Other Proteins: Metal Interaction and Aggregation”

 

20. Poster, The 122ndNationalMeetingoftheKorean Chemical Society, Daegu, Korea, October 17-19, 2018

Hyuck Jin Lee, Masha G. Savelieff, Tae Su Choi, Juhye Kang, Megan Brunjes Brophy, Toshiki G. Nakashige, Elizabeth M. Nolan, Hugh I. Kim, and Mi Hee Lim*

“Molecular-Level Studies of Amyloid-b with Other Proteins: Metal Interaction and Aggregation”

 

19. Poster, The 4th International Symposium for Molecular Neurodegenerative Disease Research,Daejeon,Korea,August22-23,2018

Hyuck Jin Lee, Tae Su Choi, Juhye Kang, Megan Brunjes Brophy, Tohiki G. Nakashige, Elizabeth M. Nolan,* Hugh I. Kim,* and Mi Hee Lim*

“Molecular Level Studies of ProteinAmyloid-b Interactions”

 

18. Oral Presentation, Symposium on Chemistry and Life, Daejeon, Korea, August 2, 2018

Hyuck Jin Lee, Tae Su Choi, Juhye Kang, Megan Brunjes Brophy, Tohiki G. Nakashige, Elizabeth M. Nolan,* Hugh I. Kim,* and Mi Hee Lim*

“Molecular Level Studies of ProteinAmyloid-b Interactions”

 

17. Poster, The 2018 Bioinorganic Chemistry Symposium, Suanbo, Korea, July 19-20, 2018

Tae Su Choi, HyuckJinLee, Jong Yoon Han, Mi Hee Lim,* and Hugh I. Kim*

“Molecular Insights into Human Serum Albumin as a Receptor of Amyloid-b in the Extracellular Region”

 

16. Oral Presentation, The Korea Chemical Society Inorganic Chemistry Division Summer Symposium, Busan, Korea, June 29, 2018

Hyuck Jin Lee and Mi Hee Lim*

“Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease”

 

15. Poster, The Korea Chemical Society Inorganic Chemistry Division Summer Symposium, Busan, Korea, June 29, 2018

Hyuck Jin Lee and Mi Hee Lim*

“Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease”

 

14. Poster, The Yeongnam Region Symposium of Korean Chemical Society, Ulsan, Korea, August 16, 2017

Hyuck Jin Lee, Kyle Korshavn, Younwoo Nam, Thomas J. Paul, Richard A. Kerr, Il-Seung Youn, Il Seung Youn, Juhye Kang, Mehmet Ozbil, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease”

 

13. Poster, The 2017 Bioinorganic Chemistry Symposium, Suanbo, Korea, July 19-20, 2017

Hyuck Jin Lee, Kyle Korshavn, Younwoo Nam, Thomas J. Paul, Richard A. Kerr, Il-Seung Youn, Il Seung Youn, Juhye Kang, Mehmet Ozbil, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease”

 

12. Oral Presentation, The 119thNationalMeetingoftheKorean Chemical Society, Ilsan, Korea, April 19-21, 2017

Hyuck Jin Lee and Mi Hee Lim*

“Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-related Pathological Features in Alzheimer’s Disease”

 

11. Poster, The 2016 Bioinorganic Chemistry Symposium, Suanbo, Korea, July 18-19, 2016

Hyuck Jin Lee, Kyle Korshavn, Younwoo Nam, Mehmet Ozbil, Richard A. Kerr, Il-Seung Youn, Woo Jong Cho, Juhye Kang, Kwang S. Kim, Brandon T. Ruotolo, Rajeev Prabhakar,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Key Structures of Chemical Tools for Modulation of Individual and Inter-related Reactivities of Amyloid-b, Metals, and Oxidative Stress in Alzheimer’s Disease”

*Note: This poster was awarded.

 

10. Oral Presentation, The 5th International Symposiumon Metallomics, Beijing ,September 9-12 ,2015

Hyuck Jin Lee, Richard A. Kerr, Kyle J. Korshavn, Jeeyeon Lee, Juhye Kang, Ayyalusamy Ramamoorthy,* Brandon T. Ruotolo,* and Mi Hee Lim*

“Effects of Hydroxyl Group Variations on A Flavonoid Backbone toward Modulation of Amyloid-b Aggregation Pathways”

 

9. Poster, The Yeongnam Region Symposium of Korean Chemical Society, Busan, Korea, August 28, 2015

Hyuck Jin Lee, Richard A. Kerr, Kyle J. Korshavn, Jeeyeon Lee, Juhye Kang, Ayyalusamy Ramamoorthy,* Brandon T. Ruotolo,* and Mi Hee Lim*

“Effects of Hydroxyl Group Variations on A Flavonoid Backbone toward Modulation of Metal-Free and Metal-Induced Amyloid-b Aggregation”

 

8. Poster, The 8th International Chem CommSymposia,Ulsan,Korea,August12,2015

Hyuck Jin Lee, Kyle J. Korshavn, Jeeyeon Lee, Juhye Kang, Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Effects of Hydroxyl Group Variations on A Flavonoid Backbone toward Modulation of Metal-Free and Metal-Induced Amyloid-b Aggregation”

 

7. Oral Presentation, The 2015 Bioinorganic Chemistry Symposium, Suanbo, Korea, July 10-11, 2015

Hyuck Jin Lee, Kyle Korshavn, Jeeyeon Lee, Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Effects of Hydroxyl Group Variation on a Flavonoid Backbone toward Modulation of Metal-Free and Metal-Induced Amyloid-b Aggregation Pathways”

 

6. Poster, The 7th Asian BiologicalInorganic Chemistry Conference ,Gold Coast ,Australia, November 30-December 5, 2014

Hyuck Jin Lee, Jeeyeon Lee, Alaina S. DeToma and Mi Hee Lim*

“Influence of Biomacromolecules on Aggregation and Reactivity of Amyloid-b Species Associated with Alzheimer’s Disease”

 

 

 

5. Poster, The 2014 Bioinorganic Chemistry Symposium, Suanbo, Korea, July 11-12, 2014

Alaina S. DeToma, Janarthanan Krishnamoorthy, Younwoo Nam, HyuckJinLee, Jeffrey R. Brender, Akiko Kochi, Valentina Onnis, Cenzo Congiu, Gianfranco Balboni,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-b Species”

 

4. Poster, The 112nd National Meeting of the Korean Chemical Society ,Changwon ,Korea ,October16-18,2013

Alaina S. DeToma, JanarthananKrishnamoorthy, JeffreyR.Brender, AkikoKochi, HyuckJinLee, Valentina Onnis, Cenzo Congiu, Gianfranco Balboni,* Ayyalusamy Ramamoorthy,* and Mi Hee Lim*

“Synthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-b Species”

 

3. Poster, The 32nd Midwest Enzyme Chemistry Conference ,Chicago ,IL,October13,2012

Tad Ogorzalek, McKenna Schroeder, HyuckJinLee, Yuwei Lie, Lei Shen, Zhan Chen, and Neil Marsh*

“Characterizing the Mechanistic Behavior of Immobilized Enzymes Using Vibrational spectroscopy”

 

2. Poster, The Undergraduate Research Conference, Minnesota State University, Mankato, MN, April 4, 2011

Hyuck Jin Lee and James Rife*

“Using Q-PCR to Measure Effects on Nitrogen Supplementation of the Expression of Lipoxygenase Isoenzymes in Soy Beans”

 

1. Oral Presentation, The Undergraduate Research Conference, Minnesota State University, Mankato, MN, April 5, 2010

Yu-Jeong Kim, Jaehwan Byun, HyuckJinLee, Namyong Lee,* and

“Mathematical Modeling of AIDS and Optimal strategies for chemotherapy”

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